Ontology highlight
ABSTRACT:
SUBMITTER: Azhar M
PROVIDER: S-EPMC3337781 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Azhar Mohamad M Brown Kristen K Gard Connie C Chen Hwudaurw H Rajan Sudarsan S Elliott David A DA Stevens Mark V MV Camenisch Todd D TD Conway Simon J SJ Doetschman Thomas T
Developmental dynamics : an official publication of the American Association of Anatomists 20110720 9
Although the function of transforming growth factor beta2 (TGFβ2) in epithelial mesenchymal transition (EMT) is well studied, its role in valve remodeling remains to be fully explored. Here, we used histological, morphometric, immunohistochemical and molecular approaches and showed that significant dysregulation of major extracellular matrix (ECM) components contributed to valve remodeling defects in Tgfb2(-/-) embryos. The data indicated that cushion mesenchymal cell differentiation was impaire ...[more]