Ontology highlight
ABSTRACT:
SUBMITTER: Chakrabarti M
PROVIDER: S-EPMC7344558 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chakrabarti Mrinmay M Al-Sammarraie Nadia N Gebere Mengistu G MG Bhattacharya Aniket A Chopra Sunita S Johnson John J Peña Edsel A EA Eberth John F JF Poelmann Robert E RE Gittenberger-de Groot Adriana C AC Azhar Mohamad M
Journal of cardiovascular development and disease 20200524 2
Transforming growth factor beta3 (<i>TGFB3</i>) gene mutations in patients of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD1) and Loeys-Dietz syndrome-5 (LDS5)/Rienhoff syndrome are associated with cardiomyopathy, cardiac arrhythmia, cardiac fibrosis, cleft palate, aortic aneurysms, and valvular heart disease. Although the developing heart of embryos express <i>Tgfb3</i>, its overarching role remains unclear in cardiovascular development and disease. We used histological, immun ...[more]