Ontology highlight
ABSTRACT:
SUBMITTER: Russo A
PROVIDER: S-EPMC3337884 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Oncogene 20120123 46
Intersectin 1 (ITSN1) is a scaffold protein that regulates diverse cellular pathways, including endocytosis and several signal transduction pathways, including phosphatidylinositol 3-kinase, Class IIβ (PI3K-C2β). ITSN1's transforming potential in vitro suggests that this scaffold protein may be involved in human tumorigenesis. Herein, we demonstrate that ITSN1 is expressed in primary human neuroblastoma tumors and tumor cell lines and is necessary for their in vitro and in vivo tumorigenic prope ...[more]