Ontology highlight
ABSTRACT:
SUBMITTER: Carter DR
PROVIDER: S-EPMC5423163 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Molecular oncology 20160302 6
The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patients and has been identified as a key driver of tumorigenesis. However, the mechanism by which MYCN promotes tumor initiation is poorly understood. Here we conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma, compared to non-malignant ganglia from wildtype littermates. We found that metabolites involved in the biosynthe ...[more]