Ontology highlight
ABSTRACT:
SUBMITTER: Chinnery HR
PROVIDER: S-EPMC3338340 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chinnery Holly R HR McLenachan Samuel S Binz Nicolette N Sun Yan Y Forrester John V JV Degli-Esposti Mariapia A MA Pearlman Eric E McMenamin Paul G PG
The American journal of pathology 20111112 1
During bacterial and viral infections, unmethylated CpG-DNA released by proliferating and dying microbes is recognized by toll-like receptor (TLR) 9 in host cells, initiating innate immune responses. Many corneal infections occur secondary to epithelial breaches and represent a major cause of vision impairment and blindness globally. To mimic this clinical situation, we investigated mechanisms of TLR9 ligand-induced corneal inflammation in mice after epithelial debridement. Application of CpG ol ...[more]