Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC6481147 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wu Jing J Li Shuang S Li Tete T Lv Xinping X Zhang Mingyou M Zang Guoxia G Qi Chong C Liu Yong-Jun YJ Xu Liang L Chen Jingtao J
Journal of immunology research 20190409
Plasmacytoid dendritic cells (pDCs) express high levels of the toll-like receptors (TLRs) TLR7 and TLR9. In response to TLR7 and TLR9 ligands, pDCs are primary producers of type I interferons. Our previous study demonstrated that pDCs activated by the TLR7 ligand imiquimod (IMQ) and the TLR9 ligand CpG A can kill breast cancer cells <i>in vitro</i> and inhibit tumor growth in vivo. Moreover, we observed a distinctive morphological, phenotypic change in pDCs after activation by IMQ and CpG A. How ...[more]