Ontology highlight
ABSTRACT:
SUBMITTER: Arigoni M
PROVIDER: S-EPMC3338916 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Arigoni Maddalena M Barutello Giuseppina G Lanzardo Stefania S Longo Dario D Aime Silvio S Curcio Claudia C Iezzi Manuela M Zheng Yujuan Y Barkefors Irmeli I Holmgren Lars L Cavallo Federica F
Angiogenesis 20120317 2
Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues. We have shown that a DNA vaccine targeting Amot overcome immune tolerance and induce an antibody response that hampers the progression of incipient tumors. Following our observation of increased Amot expression on tumor endothelia concomitant with the progression from pre-neoplastic lesions to full-fledged carcinoma, we evaluated the effect of anti-Amot vaccination on clinicall ...[more]