Ontology highlight
ABSTRACT:
SUBMITTER: Holmgren L
PROVIDER: S-EPMC1482591 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Holmgren Lars L Ambrosino Elena E Birot Olivier O Tullus Carl C Veitonmäki Niina N Levchenko Tetyana T Carlson Lena-Maria LM Musiani Piero P Iezzi Manuela M Curcio Claudia C Forni Guido G Cavallo Federica F Kiessling Rolf R
Proceedings of the National Academy of Sciences of the United States of America 20060605 24
Endogenous angiogenesis inhibitors have shown promise in preclinical trials, but clinical use has been hindered by low half-life in circulation and high production costs. Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination. The vaccination procedure generated antibodies that detected Amot on the endothelial cell surface. Purified Ig bound to the endothelial cell membrane and inhibited endothelial cell migration. In vivo, DNA vaccination blocked ...[more]