Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad I
PROVIDER: S-EPMC3339826 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ahmad Imran I Sansom Owen J OJ Leung Hing Y HY
Disease models & mechanisms 20120315 3
Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies worldwide, causing considerable morbidity and mortality. It is unusual among the epithelial carcinomas because tumorigenesis can occur by two distinct pathways: low-grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS, whereas high-grade, muscle-invasive tumours with metastatic potential generally have defects in the pathways controlled by the tumour suppressors p53 and retino ...[more]