Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.
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ABSTRACT:
SUBMITTER: Croken MM
PROVIDER: S-EPMC3340475 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.
Croken Matthew M MM Nardelli Sheila C SC Kim Kami K
Trends in parasitology 20120403 5
Chromatin structure plays a vital role in epigenetic regulation of protozoan parasite gene expression. Epigenetic gene regulation impacts upon parasite virulence, differentiation and cell-cycle control. Recent work in many laboratories has elucidated the functions of proteins that regulate parasite gene expression by chemical modification of constituent nucleosomes. A major focus of investigation has been the characterization of post-translational modifications (PTMs) of histones and the identif ...[more]
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