Ontology highlight
ABSTRACT:
SUBMITTER: Grover RK
PROVIDER: S-EPMC3341022 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Grover Rajesh K RK Cheng Julong J Peng Yingjie Y Jones Teresa M TM Ruiz Diana I DI Ulevitch Richard J RJ Glass John I JI Dennis Edward A EA Salomon Daniel R DR Lerner Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20120406 16
The mechanism of chronic rejection of transplanted human kidneys is unknown. An understanding of this process is important because, chronic rejection ultimately leads to loss of the kidney allograft in most transplants. One feature of chronic rejection is the infiltration of ectopic B-cell clusters that are clonal into the transplanted kidney. We now show that the antibodies produced by these B-cells react strongly with the core carbohydrate region of LPS. Since LPS is a costimulatory immunogen ...[more]