Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC3341051 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Zhang Jie J de Toledo Sonia M SM Pandey Badri N BN Guo Guozheng G Pain Debkumar D Li Hong H Azzam Edouard I EI
Proceedings of the National Academy of Sciences of the United States of America 20120326 16
The translationally controlled tumor protein (TCTP) is essential for survival by mechanisms that as yet are incompletely defined. Here we describe an important role of TCTP in response to DNA damage. Upon exposure of normal human cells to low-dose γ rays, the TCTP protein level was greatly increased, with a significant enrichment in nuclei. TCTP up-regulation occurred in a manner dependent on ataxia-telangiectasia mutated (ATM) kinase and the DNA-dependent protein kinase and was associated with ...[more]