Ontology highlight
ABSTRACT:
SUBMITTER: Kwon YV
PROVIDER: S-EPMC6936429 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Kwon Young V YV Zhao Bingqing B Xu Chiwei C Lee Jiae J Chen Chiao-Lin CL Vinayagam Arunachalam A Edgar Bruce A BA Perrimon Norbert N
Proceedings of the National Academy of Sciences of the United States of America 20191216 52
Translationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellular processes, ranging from growth to immune responses. To explore the role of TCTP in tissue maintenance and regeneration, we employed the adult <i>Drosophila</i> midgut, where multiple signaling pathways interact to precisely regulate stem cell division for tissue homeostasis. Tctp levels were significantly increased in stem cells and enteroblasts upon tissue damage or activation of the H ...[more]