Ontology highlight
ABSTRACT:
SUBMITTER: Ilangovan U
PROVIDER: S-EPMC33421 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20010501 11
Surface proteins of Gram-positive bacteria play important roles during the pathogenesis of human infections and require sortase for anchoring to the cell-wall envelope. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine (T) and the amino group of cell-wall crossbridges. The NMR structure of sortase reveals a unique beta-barrel structure, in which the active-site sulfhydryl of cysteine-184 is poised for ionizati ...[more]