Ontology highlight
ABSTRACT:
SUBMITTER: Suree N
PROVIDER: S-EPMC2888031 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Suree Nuttee N Yi Sung Wook SW Thieu William W Marohn Melanie M Damoiseaux Robert R Chan Albert A Jung Michael E ME Clubb Robert T RT
Bioorganic & medicinal chemistry 20090906 20
Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazin ...[more]