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Transcription factor ROR? is critical for nuocyte development.

ABSTRACT: Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor ROR? was critical for the development of nuocytes and their role in the expulsion of parasitic worms.

SUBMITTER: Wong SH

PROVIDER: S-EPMC3343633 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Transcription factor RORα is critical for nuocyte development.

Wong See Heng SH Walker Jennifer A JA Jolin Helen E HE Drynan Lesley F LF Hams Emily E Camelo Ana A Barlow Jillian L JL Neill Daniel R DR Panova Veera V Koch Ute U Radtke Freddy F Hardman Clare S CS Hwang You Yi YY Fallon Padraic G PG McKenzie Andrew N J AN

Nature immunology 20120122 3

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, althoug ...[more]

PMID: 22267218

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