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The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

ABSTRACT: Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costimulatory molecules and chemokine production. Furthermore, TH2 responses in mice with DC-specific loss of STAT5 resembled those seen in mice deficient in the receptor for TSLP. Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces.

SUBMITTER: Bell BD

PROVIDER: S-EPMC4161284 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Bell Bryan D BD Kitajima Masayuki M Larson Ryan P RP Stoklasek Thomas A TA Dang Kristen K Sakamoto Kazuhito K Wagner Kay-Uwe KU Kaplan Daniel H DH Reizis Boris B Hennighausen Lothar L Ziegler Steven F SF

Nature immunology 20130224 4

Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costi ...[more]

PMID: 23435120

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