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N-(3-Chloro-4-fluoro-phen-yl)acetamide.

ABSTRACT: In the title compound, C(8)H(7)ClFNO, the dihedral angle between the benzene ring and the acetamide side chain is 5.47?(6)°. An S(6) ring motif is formed via an intra-molecular C-H?O hydrogen bond. In the crystal, N-H?O hydrogen bonds link the mol-ecules into C(4) chains along [001].

SUBMITTER: Fun HK

PROVIDER: S-EPMC3344482 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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N-(3-Chloro-4-fluoro-phen-yl)acetamide.

Fun Hoong-Kun HK Loh Wan-Sin WS Shetty Divya N DN Narayana B B Sarojini B K BK

Acta crystallographica. Section E, Structure reports online 20120413 Pt 5

In the title compound, C(8)H(7)ClFNO, the dihedral angle between the benzene ring and the acetamide side chain is 5.47 (6)°. An S(6) ring motif is formed via an intra-molecular C-H⋯O hydrogen bond. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into C(4) chains along [001]. ...[more]

PMID: 22590244

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2-Chloro-N-(4-fluoro-phen-yl)acetamide.

Project description:In the title compound, C(8)H(7)ClFNO, an intra-molecular C-H?O hydrogen bond forms a six-membered ring. In the crystal structure, mol-ecules are linked by inter-molecular N-H?O hydrogen bonds, forming infinite chains along the c axis.

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2-(4-Bromo-phen-yl)-N-(3-chloro-4-fluoro-phen-yl)acetamide.

Project description:In the title compound, C(14)H(10)BrClFNO, the benzene rings form a dihedral angle of 64.0?(2)°. In the crystal, mol-ecules are linked via inter-molecular N-H?O, C-H?O, C-H?Cl and C-H?F hydrogen bonds into layers parallel to (001). The crystal was refined as a merohedral twin with a 0.935?(114):0.065?(14) domain ratio.

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Crystal structure of 2-chloro-N-(3-fluoro-phen-yl)acetamide.

Project description:In the title compound, C8H7ClFNO, the F atom is disordred over the meta positions of the benzene ring in a 0.574?(4):0.426?(4) ratio and the Cl atom is syn to the O atom [O-C-C-Cl = 5.6?(3)°]. A short intra-molecular C-H?O contact occurs. In the crystal, mol-ecules are linked into amide C(4) chains propagating in [101] by N-H?O hydrogen bonds.

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2-(4-Chloro-phen-yl)-N-(3,4-di-fluoro-phen-yl)acetamide.

Project description:In the title compound, C14H10ClF2NO, the dihedral angle between the mean planes of the 4-chloro-phenyl and 3,4-di-fluoro-phenyl rings is 65.2?(1)°. These two planes are twisted by 83.5?(5) and 38.9?(9)°, respectively, from that of the acetamide group. In the crystal, N-H?O hydrogen bonds form infinite chains along [100]. Weak C-H?O and C-H?F inter-actions are also observed and stack mol-ecules along the b axis.

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N-(3-Chloro-phen-yl)acetamide.

Project description:The conformation of the N-H bond in the structure of the title compound (3CPA), C(8)H(8)ClNO, is anti to the meta-chloro substituent, in contrast to the syn conformation observed for the ortho-chloro substituent in N-(2-chloro-phen-yl)acetamide, syn to both the ortho and meta chloro substituents in N-(2,3-dichloro-phen-yl)acetamide, and syn to the ortho chloro substituent in N-(2,4-dichloro-phen-yl)acetamide. There are two mol-ecules, linked by an N-H?O hydrogen bond, in the asymmetric unit of 3CPA. The bond parameters in 3CPA are similar to those of other acetanilides and the mol-ecules are packed into chains through inter-molecular N-H?O hydrogen bonds.

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2-(4-Chloro-phen-yl)acetamide.

Project description:In the title compound, C(8)H(8)ClNO, the acetamide group is twisted out the benzene plane with a dihedral angle of 83.08 (1)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, forming layers parallel to the ab plane.

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2-Chloro-N-(3-chloro-phen-yl)acetamide.

Project description:The N-H bond in the title compound, C(8)H(7)Cl(2)NO, is anti to the meta-chloro substituent in the aromatic ring in both independent mol-ecules comprising the asymmetric unit. The C=O bond is anti to the N-H bond and is also anti to the methyl-ene H atoms. Inter-molecular N-H?O hydrogen bonds link the mol-ecules into supra-molecular chains.

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N-[(4-Chloro-phen-yl)sulfon-yl]acetamide.

Project description:The asymmetric unit of the title compound, C(8)H(8)ClNO(3)S, consists of two crystallographically independent mol-ecules (A and B). The dihedral angles between the benzene ring and amide C-C(=O)-NH- plane are 87.6?(3) (mol-ecule A) and 86.0?(3)° (mol-ecule B). In the crystal, the independent mol-ecules are alternately linked by N-H?O hydrogen bonds into an infinite chain along the b axis. Short inter-molecular Cl?Cl contacts [3.2882?(5) and 3.2812?(5)?Å] are also observed.

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N-Acetyl-N-{2-[(Z)-2-chloro-3,3,3-tri-fluoro-prop-1-en-yl]phen-yl}acetamide.

Project description:The title compound, C(13)H(11)ClF(3)NO(2), adopts a Z conformation. Halogen?oxygen inter-actions [Cl?O = 2.967?(3)?Å] in the crystal packing lead to the formation of a dimer joined by two Cl?O bonds.

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