Ontology highlight
ABSTRACT:
SUBMITTER: Westerman BA
PROVIDER: S-EPMC3344841 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Westerman Bart A BA Blom Marleen M Tanger Ellen E van der Valk Martin M Song Ji-Ying JY van Santen Marije M Gadiot Jules J Cornelissen-Steijger Paulien P Zevenhoven John J Prosser Haydn M HM Uren Anthony A Aronica Eleonora E van Lohuizen Maarten M
PloS one 20120504 5
Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural origin. Although genetic depletion of Bmi1 has been described to result in tumor inhibitory effects partly through INK4A/Arf mediated senescence and apoptosis and also through INK4A/Arf independent effects, it has not been proven that Bmi1 can be cau ...[more]