Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi H
PROVIDER: S-EPMC3345098 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Kobayashi Hanako H Gilbert Victoria V Liu Qingdu Q Kapitsinou Pinelopi P PP Unger Travis L TL Rha Jennifer J Rivella Stefano S Schlöndorff Detlef D Haase Volker H VH
Journal of immunology (Baltimore, Md. : 1950) 20120406 10
Renal fibrosis and inflammation are associated with hypoxia, and tissue pO(2) plays a central role in modulating the progression of chronic kidney disease. Key mediators of cellular adaptation to hypoxia are hypoxia-inducible factor (HIF)-1 and -2. In the kidney, they are expressed in a cell type-specific manner; to what degree activation of each homolog modulates renal fibrogenesis and inflammation has not been established. To address this issue, we used Cre-loxP recombination to activate or to ...[more]