Ontology highlight
ABSTRACT:
SUBMITTER: Torres MJ
PROVIDER: S-EPMC3345106 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Torres María José MJ Turell Lucía L Botti Horacio H Antmann Laura L Carballal Sebastián S Ferrer-Sueta Gerardo G Radi Rafael R Alvarez Beatriz B
Archives of biochemistry and biophysics 20120319 1-2
The single cysteine residue of human serum albumin (HSA-SH) is the most abundant plasma thiol. HSA transports fatty acids (FA), a cargo that increases under conditions of diabetes, exercise or adrenergic stimulation. The stearic acid-HSA (5/1) complex reacted sixfold faster than FA-free HSA at pH 7.4 with the disulfide 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) and twofold faster with hydrogen peroxide and peroxynitrite. The apparent pK(a) of HSA-SH decreased from 7.9±0.1 to 7.4±0.1. Exposure to ...[more]