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Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever.

ABSTRACT: As a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate of Salmonella enterica serovar Typhi. The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment.

SUBMITTER: Koirala KD

PROVIDER: S-EPMC3346606 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever.

Koirala Kanika Deshpande KD Thanh Duy Pham DP Thapa Sudeep Dhoj SD Arjyal Amit A Karkey Abhilasha A Dongol Sabina S Shrestha Upendra Man UM Farrar Jeremy J JJ Basnyat Buddha B Baker Stephen S

Antimicrobial agents and chemotherapy 20120227 5

As a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate of Salmonella enterica serovar Typhi. The isolation of this organism ha ...[more]

PMID: 22371897

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