Ontology highlight
ABSTRACT:
SUBMITTER: Koontz JI
PROVIDER: S-EPMC33471 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20010501 11
Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stromal sarcomas, including a recurrent t(7;17)(p15;q21). We have identified two zinc finger genes, which we have termed JAZF1 and JJAZ1, at the sites of the 7p15 and 17q21 breakpoints. Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is pres ...[more]