TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.
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ABSTRACT:
SUBMITTER: Valle-Casuso JC
PROVIDER: S-EPMC3347269 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.
Valle-Casuso Jose Carlos JC Di Nunzio Francesca F Yang Yang Y Reszka Natalia N Lienlaf Maritza M Arhel Nathalie N Perez Patricio P Brass Abraham L AL Diaz-Griffero Felipe F
Journal of virology 20120307 10
TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear ...[more]
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