Ontology highlight
ABSTRACT:
SUBMITTER: Porotto M
PROVIDER: S-EPMC3347310 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Porotto Matteo M Salah Zuhair Z DeVito Ilaria I Talekar Aparna A Palmer Samantha G SG Xu Rui R Wilson Ian A IA Moscona Anne A
Journal of virology 20120321 10
The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three distinct activities contributing to the ability of HN to promote viral fusion and entry: receptor binding, receptor cleavage (neuraminidase), and activation of the fusion protein. The relationship between receptor binding and fusion triggering functions of HN are not fully understood. For Newcastle disease virus (NDV), one bifunctional site (site I) on HN's globular head can mediate both receptor binding and neuram ...[more]