Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.
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ABSTRACT:
SUBMITTER: Fender P
PROVIDER: S-EPMC3347364 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.
Fender Pascal P Hall Kathryn K Schoehn Guy G Blair G Eric GE
Journal of virology 20120215 9
During human adenovirus type 3 (Ad3) infection, an excess of penton base and fiber proteins are produced which form dodecahedral particles composed of 12 pentamers of penton base and 12 trimers of fiber protein. No biological functions have yet been ascribed to Ad3 dodecahedra. Here, we show that dodecahedra compete with Ad3 virions for binding to the cell surface and trigger cell remodeling, giving new insights into possible biological functions of dodecahedra in the Ad3 infectious cycle. ...[more]
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