Ontology highlight
ABSTRACT:
SUBMITTER: Tan L
PROVIDER: S-EPMC3347683 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20120601 11
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine, 5mC) has emerged as an important epigenetic modification that plays essential roles in development, aging and disease. However, the mechanisms controlling 5mC dynamics remain elusive. Recent studies have shown that ten-eleven translocation (Tet) proteins can catalyze 5mC oxidation and generate 5mC derivatives, including 5-hydroxymethylcytosine (5hmC). The exciting discovery of these novel 5mC derivatives ...[more]