Evaluation of high functional avidity CTL to Gag epitope clusters in EIAV carrier horses.
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ABSTRACT:
SUBMITTER: Chung C
PROVIDER: S-EPMC3348724 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Publications
Evaluation of high functional avidity CTL to Gag epitope clusters in EIAV carrier horses.
Chung Chungwon C Mealey Robert H RH McGuire Travis C TC
Virology 20050901 2
Cytotoxic T lymphocytes (CTL) are critical for lentivirus control including EIAV. Since CTL from most EIAV carrier horses recognize Gag epitope clusters (EC), the hypothesis that carrier horses would have high functional avidity CTL to optimal epitopes in Gag EC was tested. Twenty-two optimal EC epitopes were identified; two in EC1, six in EC2, and seven each in EC3 and 4. However, only five of nine horses had high functional avidity CTL (<or=11 nM) recognizing six epitopes in EC; four in relati ...[more]
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