Different evolutionary modifications as a guide to rewire two-component systems.
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ABSTRACT:
SUBMITTER: Krueger B
PROVIDER: S-EPMC3348925 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Different evolutionary modifications as a guide to rewire two-component systems.
Krueger Beate B Friedrich Torben T Förster Frank F Bernhardt Jörg J Gross Roy R Dandekar Thomas T
Bioinformatics and biology insights 20120503
Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The aim of this study is to better understand and describe rewiring of TCS while investigating different evolutionary scenarios. Based on large-scale screens of TCS in different organisms, this study gives detailed data, concrete alignments, and structure analysis ...[more]
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