Ontology highlight
ABSTRACT:
SUBMITTER: Raskatov JA
PROVIDER: S-EPMC3349014 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20120424 18
The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provide a foundation for design of DNA binding Py-Im polyamides to be tested in vivo. ...[more]