Ontology highlight
ABSTRACT:
SUBMITTER: Nasongkla N
PROVIDER: S-EPMC2668136 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090301 11
The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal thresho ...[more]