Ontology highlight
ABSTRACT:
SUBMITTER: Conde-Alvarez R
PROVIDER: S-EPMC3349745 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Conde-Álvarez Raquel R Arce-Gorvel Vilma V Iriarte Maite M Manček-Keber Mateja M Barquero-Calvo Elías E Palacios-Chaves Leyre L Chacón-Díaz Carlos C Chaves-Olarte Esteban E Martirosyan Anna A von Bargen Kristine K Grilló María-Jesús MJ Jerala Roman R Brandenburg Klaus K Llobet Enrique E Bengoechea José A JA Moreno Edgardo E Moriyón Ignacio I Gorvel Jean-Pierre JP
PLoS pathogens 20120510 5
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the gram-negative bacterium Brucella lacks a marked pathogen-associated molecular pattern, and it has been postulated that this delays the development of immunity, creating a gap that is critical for the bacterium to reach the intracellular replicative niche. We found that a B. abort ...[more]