Ontology highlight
ABSTRACT:
SUBMITTER: Miranda CJ
PROVIDER: S-EPMC3350615 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Miranda Carlos J CJ Braun Lyndsey L Jiang Yuying Y Hester Mark E ME Zhang Ling L Riolo Matthew M Wang Haijuan H Rao Meghan M Altura Rachel A RA Kaspar Brian K BK
Aging cell 20120404 3
Accumulating evidence suggests that adult hippocampal neurogenesis relies on the controlled and continued proliferation of neural progenitor cells (NPCs). With age, neurogenesis decreases through mechanisms that remain unclear but are believed to involve changes in the NPC microenvironment. Here, we provide evidence that NPC proliferation in the adult brain is in part regulated by astrocytes via Wnt signaling and that this cellular cross-talk is modified in the aging brain, leading to decreased ...[more]