Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC3351318 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Liu Zhiping Z Zaki Md Hasan MH Vogel Peter P Gurung Prajwal P Finlay B Brett BB Deng Wanyin W Lamkanfi Mohamed M Kanneganti Thirumala-Devi TD
The Journal of biological chemistry 20120329 20
Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that triggers inflammatory responses resembling those of humans infected with enteropathogenic and enterohemorrhagic Escherichia coli. Inflammasome signaling is emerging as a central regulator of inflammatory and host responses to several pathogens, but the in vivo role of inflammasome signaling in host defense against C. rodentium has not been characterized. Here, we show that mice lacking the inflammasome comp ...[more]