Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Ferras O
PROVIDER: S-EPMC3351347 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Sanchez-Ferras Oraly O Coutaud Baptiste B Djavanbakht Samani Taraneh T Tremblay Isabelle I Souchkova Ouliana O Pilon Nicolas N
The Journal of biological chemistry 20120328 20
One of the earliest events in neural crest development takes place at the neural plate border and consists in the induction of Pax3 expression by posteriorizing Wnt·β-catenin signaling. The molecular mechanism of this regulation is not well understood, but several observations suggest a role for posteriorizing Cdx transcription factors (Cdx1/2/4) in this process. Cdx genes are known as integrators of posteriorizing signals from Wnt, retinoic acid, and FGF pathways. In this work, we report that W ...[more]