Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Escobar B
PROVIDER: S-EPMC5992595 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
López-Escobar Beatriz B Caro-Vega José Manuel JM Vijayraghavan Deepthi S DS Plageman Timothy F TF Sanchez-Alcazar José A JA Moreno Roberto Carlos RC Savery Dawn D Márquez-Rivas Javier J Davidson Lance A LA Ybot-González Patricia P
Development (Cambridge, England) 20180508 9
The last stage of neural tube (NT) formation involves closure of the caudal neural plate (NP), an embryonic structure formed by neuromesodermal progenitors and newly differentiated cells that becomes incorporated into the NT. Here, we show in mouse that, as cell specification progresses, neuromesodermal progenitors and their progeny undergo significant changes in shape prior to their incorporation into the NT. The caudo-rostral progression towards differentiation is coupled to a gradual reliance ...[more]