Ontology highlight
ABSTRACT:
SUBMITTER: Tarallo V
PROVIDER: S-EPMC3351582 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cell 20120426 4
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechanism of Alu RNA-induced cytotoxicity is unknown. Here we show that DICER1 deficit or Alu RNA exposure activates the NLRP3 inflammasome and triggers TLR-independent MyD88 signaling via IL18 in the RPE. Genetic or pharmacological inhibition of inflammasome com ...[more]