Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3351833 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Chen Yanyi Y Zhou Yubin Y Lin Xianming X Wong Hing-Cheung HC Xu Qin Q Jiang Jie J Wang Siming S Lurtz Monica M MM Louis Charles F CF Veenstra Richard D RD Yang Jenny J JJ
The Biochemical journal 20110501 3
Cx50 (connexin50), a member of the α-family of gap junction proteins expressed in the lens of the eye, has been shown to be essential for normal lens development. In the present study, we identified a CaMBD [CaM (calmodulin)-binding domain] (residues 141-166) in the intracellular loop of Cx50. Elevations in intracellular Ca2+ concentration effected a 95% decline in gj (junctional conductance) of Cx50 in N2a cells that is likely to be mediated by CaM, because inclusion of the CaM inhibitor calmid ...[more]