Ontology highlight
ABSTRACT:
SUBMITTER: Patel N
PROVIDER: S-EPMC5698441 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Patel Neha N Stengel Florian F Aebersold Ruedi R Gold Matthew G MG
Nature communications 20171122 1
AKAP79/150 is essential for coordinating second messenger-responsive enzymes in processes including synaptic long-term depression. Ca<sup>2+</sup> directly regulates AKAP79 through its effector calmodulin (CaM), but the molecular basis of this regulation was previously unknown. Here, we report that CaM recognizes a '1-4-7-8' pattern of hydrophobic amino acids starting at Trp79 in AKAP79. Cross-linking coupled to mass spectrometry assisted mapping of the interaction site. Removal of the CaM-bindi ...[more]