Ontology highlight
ABSTRACT:
SUBMITTER: Bao X
PROVIDER: S-EPMC3352175 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Microbiology (Reading, England) 20110630 Pt 9
Chlamydia trachomatis, an obligate intracellular bacterium, is a highly prevalent human pathogen. Hydroxamic-acid-based matrix metalloprotease inhibitors can effectively inhibit the pathogen both in vitro and in vivo, and have exhibited therapeutic potential. Here, we provide genome sequencing data indicating that peptide deformylase (PDF) is the sole target of the inhibitors in this organism. We further report molecular mechanisms that control chlamydial PDF (cPDF) expression and inhibition eff ...[more]