Ontology highlight
ABSTRACT:
SUBMITTER: VanderWeele TJ
PROVIDER: S-EPMC3353137 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
VanderWeele Tyler J TJ Asomaning Kofi K Tchetgen Tchetgen Eric J EJ Han Younghun Y Spitz Margaret R MR Shete Sanjay S Wu Xifeng X Gaborieau Valerie V Wang Ying Y McLaughlin John J Hung Rayjean J RJ Brennan Paul P Amos Christopher I CI Christiani David C DC Lin Xihong X
American journal of epidemiology 20120203 10
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the risks of both lung cancer and nicotine dependence and associated smoking behavior. However, there remains debate as to whether the association with lung cancer is direct or is mediated by pathways related to smoking behavior. Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachuse ...[more]