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Brain-Spleen Inflammatory Coupling: A Literature Review.

ABSTRACT: Recent evidence suggests a link between brain injury and the autonomic release of pro-inflammatory cytokines by resident macrophages in the spleen. This phenomenon, termed "brain-spleen inflammatory coupling," has garnered attention from scientific and medical communities interested in developing novel treatments for traumatic brain injury (TBI). Cholinergic stimulation of the ?7-subunit nicotinic acetylcholine receptor (?7NAchR) on splenic macrophages has been shown to inhibit their release of pro-inflammatory cytokines. This inhibition, mediated by the parasympathetic nervous system, has been shown to improve outcomes in animal models of sepsis, stroke, and TBI. As evidence of a beneficial role of splenic inhibition grows, new treatment strategies might be applied to many medical conditions involving neuroinflammation, a process that contributes to further neurological deterioration.

SUBMITTER: Rasouli J

PROVIDER: S-EPMC3353810 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Brain-Spleen Inflammatory Coupling: A Literature Review.

Rasouli J J Lekhraj R R Ozbalik M M Lalezari P P Casper D D

The Einstein journal of biology and medicine : EJBM 20110101 2

Recent evidence suggests a link between brain injury and the autonomic release of pro-inflammatory cytokines by resident macrophages in the spleen. This phenomenon, termed "brain-spleen inflammatory coupling," has garnered attention from scientific and medical communities interested in developing novel treatments for traumatic brain injury (TBI). Cholinergic stimulation of the α7-subunit nicotinic acetylcholine receptor (α7NAchR) on splenic macrophages has been shown to inhibit their release of ...[more]

PMID: 22611344

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