Ontology highlight
ABSTRACT:
SUBMITTER: Donzelli S
PROVIDER: S-EPMC3354056 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cell death and differentiation 20111223 6
p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogenic functions. Here we show that p53R175H, a hotspot p53 mutant, induces microRNA (miRNA)-128-2 expression. Mutant p53 binds to the putative promoter of miR128-2 host gene, ARPP21, determining a concomitant induction of ARPP21 mRNA and miR-128-2. miR-128-2 expression in lung cancer cells inh ...[more]