Ontology highlight
ABSTRACT:
SUBMITTER: Gilmore SA
PROVIDER: S-EPMC3355658 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Gilmore Sarah A SA Schelle Michael W MW Holsclaw Cynthia M CM Leigh Clifton D CD Jain Madhulika M Cox Jeffery S JS Leary Julie A JA Bertozzi Carolyn R CR
ACS chemical biology 20120224 5
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly evolved human pathogen characterized by its formidable cell wall. Many unique lipids and glycolipids from the Mtb cell wall are thought to be virulence factors that mediate host-pathogen interactions. An intriguing example is Sulfolipid-1 (SL-1), a sulfated glycolipid that has been implicated in Mtb pathogenesis, although no direct role for SL-1 in virulence has been established. Previously, we described the bioch ...[more]