Ontology highlight
ABSTRACT:
SUBMITTER: Ruhl CR
PROVIDER: S-EPMC7102531 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ruhl Cody R CR Pasko Breanna L BL Khan Haaris S HS Kindt Lexy M LM Stamm Chelsea E CE Franco Luis H LH Hsia Connie C CC Zhou Min M Davis Colton R CR Qin Tian T Gautron Laurent L Burton Michael D MD Mejia Galo L GL Naik Dhananjay K DK Dussor Gregory G Price Theodore J TJ Shiloh Michael U MU
Cell 20200305 2
Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests with a persistent cough as both a primary symptom and mechanism of transmission. The cough reflex can be triggered by nociceptive neurons innervating the lungs, and some bacteria produce neuron-targeting molecules. However, how pulmonary Mtb infection causes cough remains undefined, and whether Mtb produces a neuron-activating, cough-inducing molecule is unknown. Here, we show that an Mtb organic extract acti ...[more]