Ontology highlight
ABSTRACT:
SUBMITTER: Amoozgar Z
PROVIDER: S-EPMC3355976 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Amoozgar Zohreh Z Park Joonyoung J Lin Qingnuo Q Yeo Yoon Y
Molecular pharmaceutics 20120420 5
When a nanoparticle is developed for systemic application, its surface is typically protected by poly(ethylene glycol) (PEG) to help prolonged circulation and evasion of immune clearance. On the other hand, PEG can interfere with interactions between nanocarriers and target cells and negatively influence the therapeutic outcomes. To overcome this challenge, we propose low molecular-weight chitosan (LMWC) as an alternative surface coating, which can protect the nanomedicine in neutral pH but allo ...[more]