Dataset Information

Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

ABSTRACT: Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR?=?0.79, 95% CI?=?0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR?=?2.3, 95% CI?=?1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR?=?2.7, 95% CI?=?1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR?=?1.2, 95% CI?=?1.1-1.4), and the GSTM1 null genotype (OR?=?1.1, 95% CI?=?1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

SUBMITTER: Chuang SC

PROVIDER: S-EPMC3356135 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

Chuang Shu-Chun SC Agudo Antonio A Ahrens Wolfgang W Anantharaman Devasena D Benhamou Simone S Boccia Stefania S Chen Chu C Conway David I DI Fabianova Eleonora E Hayes Richard B RB Healy Claire M CM Holcatova Ivana I Kjaerheim Kristina K Lagiou Pagona P Lazarus Philip P Macfarlane Tatiana V TV Mahimkar Manoj B MB Mates Dana D Matsuo Keitaro K Merletti Franco F Metspalu Andres A Morgenstern Hal H Muscat Joshua J Cadoni Gabriella G Olshan Andrew F AF Purdue Mark M Ramroth Heribert H Rudnai Peter P Schwartz Stephen M SM Simonato Lorenzo L Smith Elaine M EM Sturgis Erich M EM Szeszenia-Dabrowska Neonilia N Talamini Renato R Thomson Peter P Wei Qingyi Q Zaridze David D Zhang Zuo-Feng ZF Znaor Ariana A Brennan Paul P Boffetta Paolo P Hashibe Mia M

Frontiers in oncology 20110712

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control ...[more]

PMID: 22655231

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Project description:BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ? 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22?704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Dataset Information

Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

Publications

Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

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