Dataset Information

Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.

ABSTRACT: We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

SUBMITTER: Chuang SC

PROVIDER: S-EPMC3654401 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.

Chuang Shu-Chun SC Jenab Mazda M Heck Julia E JE Bosetti Cristina C Talamini Renato R Matsuo Keitaro K Castellsague Xavier X Franceschi Silvia S Herrero Rolando R Winn Deborah M DM La Vecchia Carlo C Morgenstern Hal H Zhang Zuo-Feng ZF Levi Fabio F Dal Maso Luigino L Kelsey Karl K McClean Michael D MD Vaughan Thomas T Lazarus Philip P Muscat Joshua J Ramroth Heribert H Chen Chu C Schwartz Stephen M SM Eluf-Neto Jose J Hayes Richard B RB Purdue Mark M Boccia Stefania S Cadoni Gabriella G Zaridze David D Koifman Sergio S Curado Maria Paula MP Ahrens Wolfgang W Benhamou Simone S Matos Elena E Lagiou Pagona P Szeszenia-Dabrowska Neonilla N Olshan Andrew F AF Fernandez Leticia L Menezes Ana A Agudo Antonio A Daudt Alexander W AW Merletti Franco F Macfarlane Gary J GJ Kjaerheim Kristina K Mates Dana D Holcatova Ivana I Schantz Stimson S Yu Guo-Pei GP Simonato Lorenzo L Brenner Hermann H Mueller Heiko H Conway David I DI Thomson Peter P Fabianova Eleonora E Znaor Ariana A Rudnai Peter P Healy Claire M CM Ferro Gilles G Brennan Paul P Boffetta Paolo P Hashibe Mia M

Cancer causes & control : CCC 20111029 1

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. ...[more]

PMID: 22037906

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Project description:BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ? 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22?704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Dataset Information

Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.

Publications

Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.

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