Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.
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ABSTRACT:
SUBMITTER: Sardar Sinha M
PROVIDER: S-EPMC6015111 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.
Sardar Sinha Maitrayee M Ansell-Schultz Anna A Civitelli Livia L Hildesjö Camilla C Larsson Max M Lannfelt Lars L Ingelsson Martin M Hallbeck Martin M
Acta neuropathologica 20180613 1
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in a prion-like manner, although the underlying mechanisms are incompletely understood. Here we show that small extracellular vesicles, exosomes, from Alzheimer patients' brains contain increased levels of amyloid-beta oligomers and can act as ve ...[more]
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