Ontology highlight
ABSTRACT:
SUBMITTER: Ahuja M
PROVIDER: S-EPMC3357392 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ahuja Manmeet M Chiang Yi-Ming YM Chang Shu-Lin SL Praseuth Mike B MB Entwistle Ruth R Sanchez James F JF Lo Hsien-Chun HC Yeh Hsu-Hua HH Oakley Berl R BR Wang Clay C C CC
Journal of the American Chemical Society 20120501 19
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways, and other genes necessary for NR-PKS product for ...[more]